Predes D, Oliveira LFS, Ferreira LSS, Maia LA, Delou JMA, Faletti A, Oliveira I, Amado NG, Reis AH, Fraga CAM, Kuster R, Mendes FA, Borges HL, Abreu JG. The Chalcone Lonchocarpin Inhibits Wnt/β-Catenin Signaling and Suppresses Colorectal Cancer Proliferation. Cancers (Basel). 2019 Dec 7;11(12):1968. doi: 10.3390/cancers11121968. PMID: 31817828; PMCID: PMC6966512.
 
Predes D, Cruz JVR, Abreu JG, Mendes FA. CUB domain-containing protein 1 (CDCP1) binds transforming growth factor beta family members and increase TGF-β1 signaling pathway. Exp Cell Res. 2019 Oct 1;383(1):111499. doi: 10.1016/j.yexcr.2019.111499. Epub 2019 Jul 11. PMID: 31302030.
 
Matias D, Dubois LG, Pontes B, Rosário L, Ferrer VP, Balça-Silva J, Fonseca ACC, Macharia LW, Romão L, E Spohr TCLS, Chimelli L, Filho PN, Lopes MC, Abreu JG, Lima FRS, Moura-Neto V. GBM-Derived Wnt3a Induces M2-Like Phenotype in Microglial Cells Through Wnt/β-Catenin Signaling. Mol Neurobiol. 2019 Feb;56(2):1517-1530. doi: 10.1007/s12035-018-1150-5. Epub 2018 Jun 14. PMID: 29948952.
 
Amaral LS, Martins Ferreira J, Predes D, Abreu JG, Noël F, Quintas LEM. Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides. Int J Mol Sci. 2018 Sep 14;19(9):2769. doi: 10.3390/ijms19092769. PMID: 30223494; PMCID: PMC6163863.
 
Cavalheiro GR, Matos-Rodrigues GE, Zhao Y, Gomes AL, Anand D, Predes D, de Lima S, Abreu JG, Zheng D, Lachke SA, Cvekl A, Martins RAP. N-myc regulates growth and fiber cell differentiation in lens development. Dev Biol. 2017 Sep 1;429(1):105-117. doi: 10.1016/j.ydbio.2017.07.002. Epub 2017 Jul 14. PMID: 28716713; PMCID: PMC5586101.
 
Maia LA, Velloso I, Abreu JG. Advances in the use of Xenopus for successful drug screening. Expert Opin Drug Discov. 2017 Nov;12(11):1153-1159. doi: 10.1080/17460441.2017.1367281. Epub 2017 Aug 28. PMID: 28846034.
 
Tortelote GG, Reis RR, de Almeida Mendes F, Abreu JG. Complexity of the Wnt/β‑catenin pathway: Searching for an activation model. Cell Signal. 2017 Dec;40:30-43. doi: 10.1016/j.cellsig.2017.08.008. Epub 2017 Aug 26. PMID: 28844868.
 
Matias D, Predes D, Niemeyer Filho P, Lopes MC, Abreu JG, Lima FRS, Moura Neto V. Microglia-glioblastoma interactions: New role for Wnt signaling. Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):333-340. doi: 10.1016/j.bbcan.2017.05.007. Epub 2017 May 26. PMID: 28554667.
 
de Lima AV, Reis AH, Amado NG, Cassiano-Lima D, Borges-Nojosa DM, Oriá RB, Abreu JG. Developmental aspects of the direct-developing frog Adelophryne maranguapensis. Genesis. 2016 May;54(5):257-71. doi: 10.1002/dvg.22935. Epub 2016 Apr 2. PMID: 26953634.
 
Reis AH, Moreno MM, Maia LA, Oliveira FP, Santos AS, Abreu JG. Cholesterol-rich membrane microdomains modulate Wnt/β-catenin morphogen gradient during Xenopus development. Mech Dev. 2016 Nov;142:30-39. doi: 10.1016/j.mod.2016.09.001. Epub 2016 Sep 26. PMID: 27687541.
 
Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT, Zebisch M, Jones EY, Abreu JG, He X. Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation. Dev Cell. 2015 Mar 23;32(6):719-30. doi: 10.1016/j.devcel.2015.02.014. Epub 2015 Mar 12. PMID: 25771893; PMCID: PMC4375027.
 
Fonseca BF, Predes D, Cerqueira DM, Reis AH, Amado NG, Cayres MC, Kuster RM, Oliveira FL, Mendes FA, Abreu JG. Derricin and derricidin inhibit Wnt/β-catenin signaling and suppress colon cancer cell growth in vitro. PLoS One. 2015 Mar 16;10(3):e0120919. doi: 10.1371/journal.pone.0120919. PMID: 25775405; PMCID: PMC4361740.
 
Cordeiro IR, Lopes DV, Abreu JG, Carneiro K, Rossi MI, Brito JM. Chick embryo xenograft model reveals a novel perineural niche for human adipose-derived stromal cells. Biol Open. 2015 Aug 28;4(9):1180-93. doi: 10.1242/bio.010256. PMID: 26319582; PMCID: PMC4582113.
 
Bezerra Lima B, Faria Fonseca B, da Graça Amado N, Moreira Lima D, Albuquerque Ribeiro R, Garcia Abreu J, de Castro Brito GA. Clostridium difficile toxin A attenuates Wnt/β-catenin signaling in intestinal epithelial cells. Infect Immun. 2014 Jul;82(7):2680-7. doi: 10.1128/IAI.00567-13. Epub 2014 Apr 7. PMID: 24711571; PMCID: PMC4097644.
 
Amado NG, Predes D, Moreno MM, Carvalho IO, Mendes FA, Abreu JG. Flavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapies. Int J Mol Sci. 2014 Jul 8;15(7):12094-106. doi: 10.3390/ijms150712094. PMID: 25007066; PMCID: PMC4139831.
 
Aguiar DP, de Farias GC, de Sousa EB, de Mattos Coelho-Aguiar J, Lobo JC, Casado PL, Duarte ME, Abreu JG Jr. New strategy to control cell migration and metastasis regulated by CCN2/CTGF. Cancer Cell Int. 2014 Jul 12;14:61. doi: 10.1186/1475-2867-14-61. PMID: 25120383; PMCID: PMC4130434.
 
Cerqueira DM, Tran U, Romaker D, Abreu JG, Wessely O. Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts. Dev Biol. 2014 Oct 1;394(1):54-64. doi: 10.1016/j.ydbio.2014.07.025. Epub 2014 Aug 12. PMID: 25127994; PMCID: PMC4163507.
 
Reis AH, Macdonald B, Feistel K, Brito JM, Amado NG, Xu C, Abreu JG, He XI. Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates. Int J Dev Biol. 2014;58(5):355-362. doi: 10.1387/ijdb.140106ja. PMID: 25354456; PMCID: PMC4528638.
 
Amado NG, Predes D, Fonseca BF, Cerqueira DM, Reis AH, Dudenhoeffer AC, Borges HL, Mendes FA, Abreu JG. Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway. J Biol Chem. 2014 Dec 19;289(51):35456-67. doi: 10.1074/jbc.M114.621599. Epub 2014 Oct 30. PMID: 25359775; PMCID: PMC4271231.
 
Amado NG, Fonseca BF, Cerqueira DM, Reis AH, Simas AB, Kuster RM, Mendes FA, Abreu JG. Effects of natural compounds on Xenopus embryogenesis: a potential read out for functional drug discovery targeting Wnt/β-catenin signaling. Curr Top Med Chem. 2012;12(19):2103-13. doi: 10.2174/156802612804910241. PMID: 23167799.
 
Romão LF, Mendes FA, Feitosa NM, Faria JC, Coelho-Aguiar JM, de Souza JM, Moura Neto V, Abreu JG. Connective tissue growth factor (CTGF/CCN2) is negatively regulated during neuron-glioblastoma interaction. PLoS One. 2013;8(1):e55605. doi: 10.1371/journal.pone.0055605. Epub 2013 Jan 31. PMID: 23383241; PMCID: PMC3561339.
 
Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT, Zhang X, Garcia Abreu J, Peng L, He X. Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies. Science. 2013 May 17;340(6134):867-70. doi: 10.1126/science.1232389. Epub 2013 Apr 11. PMID: 23579495; PMCID: PMC3788643.
 
Reis AH, Almeida-Coburn KL, Louza MP, Cerqueira DM, Aguiar DP, Silva-Cardoso L, Mendes FA, Andrade LR, Einicker-Lamas M, Atella GC, Brito JM, Abreu JG. Plasma membrane cholesterol depletion disrupts prechordal plate and affects early forebrain patterning. Dev Biol. 2012 May 15;365(2):350-62. doi: 10.1016/j.ydbio.2012.03.003. Epub 2012 Mar 9. PMID: 22426006.
 
Zhang X, Abreu JG, Yokota C, MacDonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell. 2012 Jun 22;149(7):1565-77. doi: 10.1016/j.cell.2012.04.039. PMID: 22726442; PMCID: PMC3383638.
 
Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell. 2012 Dec 7;151(6):1200-13. doi: 10.1016/j.cell.2012.11.014. PMID: 23217707; PMCID: PMC3705565.
 
Trujillo CA, Negraes PD, Schwindt TT, Lameu C, Carromeu C, Muotri AR, Pesquero JB, Cerqueira DM, Pillat MM, de Souza HD, Turaça LT, Abreu JG, Ulrich H. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. J Biol Chem. 2012 Dec 28;287(53):44046-61. doi: 10.1074/jbc.M112.407197. Epub 2012 Nov 6. PMID: 23132855; PMCID: PMC3531721.
 
Aguiar DP, Coelho-Aguiar JM, Abreu JG. CCN2/CTGF silencing blocks cell aggregation in embryonal carcinoma P19 cell. Braz J Med Biol Res. 2011 Mar;44(3):200-5. doi: 10.1590/s0100-879x2011007500019. Epub 2011 Feb 18. PMID: 21344133.
 
Amado NG, Fonseca BF, Cerqueira DM, Neto VM, Abreu JG. Flavonoids: potential Wnt/beta-catenin signaling modulators in cancer. Life Sci. 2011 Oct 10;89(15-16):545-54. doi: 10.1016/j.lfs.2011.05.003. Epub 2011 May 18. PMID: 21635906.
 
Aguiar DP, Pontes B, Mendes FA, Andrade LR, Viana NB, Abreu JG. CTGF/CCN2 has a chemoattractive function but a weak adhesive property to embryonic carcinoma cells. Biochem Biophys Res Commun. 2011 Oct 7;413(4):582-7. doi: 10.1016/j.bbrc.2011.09.005. Epub 2011 Sep 8. PMID: 21925146.
 
Zhang B, Abreu JG, Zhou K, Chen Y, Hu Y, Zhou T, He X, Ma JX. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6900-5. doi: 10.1073/pnas.0906764107. Epub 2010 Mar 29. PMID: 20351274; PMCID: PMC2872418.
 
Castillo HA, Cravo RM, Azambuja AP, Simões-Costa MS, Sura-Trueba S, Gonzalez J, Slonimsky E, Almeida K, Abreu JG, de Almeida MA, Sobreira TP, de Oliveira SH, de Oliveira PS, Signore IA, Colombo A, Concha ML, Spengler TS, Bronner-Fraser M, Nobrega M, Rosenthal N, Xavier-Neto J. Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer. Development. 2010 Feb;137(3):507-18. doi: 10.1242/dev.043257. PMID: 20081195; PMCID: PMC4074295.
 
Thiago LS, Costa ES, Lopes DV, Otazu IB, Nowill AE, Mendes FA, Portilho DM, Abreu JG, Mermelstein CS, Orfao A, Rossi MI, Borojevic R. The Wnt signaling pathway regulates Nalm-16 b-cell precursor acute lymphoblastic leukemic cell line survival and etoposide resistance. Biomed Pharmacother. 2010 Jan;64(1):63-72. doi: 10.1016/j.biopha.2009.09.005. Epub 2009 Oct 27. PMID: 19864107.
 
Wu G, Huang H, Garcia Abreu J, He X. Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. PLoS One. 2009;4(3):e4926. doi: 10.1371/journal.pone.0004926. Epub 2009 Mar 18. PMID: 19293931; PMCID: PMC2654145.
 
Cardoso JF, Mendes FA, Amadeu TP, Romana-Souza B, Valença SS, Porto LC, Abreu JG, Monte-Alto-Costa A. Ccn2/Ctgf overexpression induced by cigarette smoke during cutaneous wound healing is strain dependent. Toxicol Pathol. 2009 Feb;37(2):175-82. doi: 10.1177/0192623308328134. PMID: 19332661.
 
Amado NG, Cerqueira DM, Menezes FS, da Silva JF, Neto VM, Abreu JG. Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes beta-catenin cellular localization. Anticancer Drugs. 2009 Aug;20(7):543-52. doi: 10.1097/CAD.0b013e32832d1149. PMID: 19491660.
 
Pacheco MS, Reis AH, Aguiar DP, Lyons KM, Abreu JG. Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development. Cells Tissues Organs. 2008;187(3):199-210. doi: 10.1159/000112640. Epub 2007 Dec 17. PMID: 18089935; PMCID: PMC2760595.
 
Magdesian MH, Carvalho MM, Mendes FA, Saraiva LM, Juliano MA, Juliano L, Garcia-Abreu J, Ferreira ST. Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem. 2008 Apr 4;283(14):9359-68. doi: 10.1074/jbc.M707108200. Epub 2008 Jan 30. PMID: 18234671; PMCID: PMC2431018.